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Certainly, opioid medications continue being Amongst the most generally prescribed analgesics to deal with average to critical acute pain, but their use frequently leads to respiratory melancholy, nausea and constipation, as well as dependancy and tolerance.Tabernaemontana divaricata Conolidine is undoubtedly an indole alkaloid. Preliminary studies
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which has been Utilized in conventional Chinese, Ayurvedic, and Thai drugs, signifies the beginning of a new era of Serious suffering management (11). This information will examine and summarize The existing therapeutic modalities of Continual pain along with the therapeutic Homes of conolidine.The "Up-to-date" day suggests when new information was